DLL1 CHO
CBP74619
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| I. Background | |
| DLL1（Delta-like protein 1）是Notch信号通路的关键配体，顺利获得与邻近细胞表面的Notch受体（如NOTCH1、NOTCH2、NOTCH3）结合，激活下游信号，调控细胞分化、增殖与命运决定。它在胚胎发育、神经发生、肌肉形成、免疫系统成熟及成体干细胞维持中发挥不可或缺的作用。其基因突变与常染色体显性遗传的NEDBAS（伴或不伴癫痫的神经发育障碍）相关；在肿瘤微环境中，DLL1还可招募并极化免疫抑制性巨噬细胞，参与免疫逃逸。 | |
| II. Description | |
| DLL1 CHO细胞，在 CHO-K1 细胞的基础上，稳定表达 DLL1 。 | |
| III. Introduction | |
| Expressed gene: | DLL1 |
| Host Cell: | CHO |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10%FBS+600 μg/ml Hygromycin B |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| IV. Representative Data | |
 Figure 1. Recombinant DLL1 CHO constitutively expressing DLL1. |
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